What is the function of selectin?

What is the function of selectin?

The selectins are cell surface lectins that have evolved to mediate the adhesion of white blood cells to endothelial cells and platelets under flow. They recognize fucosylated, sialylated and in some cases sulfated ligands expressed on scaffold glycoproteins serving as functional counter-receptors.

Is selectin a protein?

Selectins are a family of transmembrane proteins containing an amino-terminal lectin domain for binding to ligands, an epidermal growth factor (EGF)-like domain, 2–9 regulatory protein repeats, a transmembrane domain, and a short cytoplasmic tail.

Are selectins carbohydrates?

The selectins are a family of carbohydrate-binding proteins that have been implicated in the initial interaction between leukocytes and the vascular endothelium.

What does P-selectin bind to?

When endothelial cells are activated by molecules such as histamine or thrombin during inflammation, P-selectin moves from an internal cell location to the endothelial cell surface. P-selectin attaches to the actin cytoskeleton through anchor proteins that are still poorly characterized.

Is ICAM a selectin?

P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice.

Is P-selectin and integrin?

P-selectin and PSGL-1 constitute the main receptor–ligand pair that mediates physical interactions between platelets and leukocytes. Activation of the leukocyte β1 and β2 integrins involves functional upregulation and activation-dependent conformational changes necessary for the integrins to recognize their ligands.

Where does P-selectin come from?

P-selectin is a 140 kD protein found in the alpha-granules of platelets and the Weibel-Palade bodies of endothelial cells. On cell activation it is expressed on the cell surface and also secreted into plasma.

What does CD62L bind to?

Leukocyte selectin (L-selectin, CD62L) binds preferentially to O-linked carbohydrates present on a small number of mucin-like glycoproteins, such as glycosylation-dependent cell adhesion molecule-1 (GlyCAM-1), expressed in high endothelial venules.

What do selectins interact with?

Selectins are a family of cell surface lectins that mediate leucocyte-endothelial cell interactions in inflammatory and immune reactions by binding sialylated, fucosylated, and sometimes sulphated carbohydrate ligands.

What does ICAM stand for?

Intercellular Adhesion Molecule
ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system.

What does VCAM stand for?

Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene.

What are lectins and what do they do?

Lectin. Lectins are carbohydrate -binding proteins, macromolecules that are highly specific for sugar moieties of other molecules. Lectins perform recognition on the cellular and molecular level and play numerous roles in biological recognition phenomena involving cells, carbohydrates, and proteins.

What is the meaning of the word selectin?

Here are all the possible meanings and translations of the word selectin. Selectins are a family of cell adhesion molecules. All selectins are single-chain transmembrane glycoproteins that share similar properties to C-type lectins due to a related amino terminus and calcium-dependent binding.

How are selectins similar to C type lectins?

Selectins are a family of cell adhesion molecules. All selectins are single-chain transmembrane glycoproteins that share similar properties to C-type lectins due to a related amino terminus and calcium-dependent binding. Selectins bind to sugar moieties and so are considered to be a type of lectin, cell adhesion proteins that bind sugar polymers.

What kind of lectins are found in castor beans?

For his doctoral thesis at the University of Dorpat, he presented his findings from an experiment where he isolated ricin, a type of toxic lectin that is found in castor beans. In the years that followed, scientists began gaining a deeper understanding of the role that lectins play in both the diet and in nature.

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