What is the meaning of peroxisome proliferator?

What is the meaning of peroxisome proliferator?

Peroxisome proliferators (PPs) are a diverse group of chemicals with dissimilar structures capable of producing pleiotropic responses in experimental animals. These are classified as nongenotoxic carcinogens but are prolific inducers of rodent liver cancer when administered chronically.

What activates peroxisome proliferator?

PPARs are activated by endogenous ligands that are derived from the metabolism of fatty acids and other compounds that are found in the diet, which is consistent with the fact that PPARs regulate the expression of many genes involved in glucose and lipid metabolism1.

What is PPARs function?

PPARs are members of the supergene family of nuclear receptors that function as transcription factors regulating the expression of genes involved in cellular intermediary metabolism and inflammation.

How are PPARs activated?

PPARs are transcription factors, activated by binding key metabolic ligands, which exert their effects at the level of DNA to alter gene expression.

What does proliferator mean?

intr. 1. To grow or multiply by rapidly producing new tissue, parts, cells, or offspring. 2. To increase or spread at a rapid rate: fears that nuclear weapons might proliferate.

Where are PPARs located?

PPARG is mainly present in adipose tissue, colon and macrophages. Two isoforms of PPARG are detected in the human and in the mouse: PPAR-γ1 (found in nearly all tissues except muscle) and PPAR-γ2 (mostly found in adipose tissue and the intestine).

What are the benefits of PPARs?

PPAR 𝛾 is involved in glucose metabolism through the improvement of insulin sensitivity and represents a potential therapeutic target of type 2 diabetes. Thus PPARs are molecular targets for the development of drugs treating metabolic syndrome. However, PPARs also play a role in the regulation of cancer cell growth.

What is PPARs HSE?

THE PPARS (personnel, payroll and related systems) computer system used by the HSE was a disaster.

Where are PPARs found?

ISOFORMS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS γ1 – expressed in virtually all tissues, including heart, muscle, colon, kidney, pancreas, and spleen. γ2 – expressed mainly in adipose tissue (30 amino acids longer). γ3 – expressed in macrophages, large intestine, and white adipose tissue.

Is proliferator a word?

pro·lif·er·ate To grow or multiply by rapidly producing new tissue, parts, cells, or offspring. 2. To increase or spread at a rapid rate: fears that nuclear weapons might proliferate.

How are PPARs used to induce peroxisome proliferation?

PPARs were so-named because they were discovered to induce peroxisome proliferation in rodents, but induction of peroxisome proliferation is not believed to occur in humans. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes.

What are the subtypes of peroxisome proliferator activated receptors?

This article has been cited byother articles in PMC. Abstract Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ.

Where are peroxisomes found in plant and animal cells?

Peroxisomes are subcellular organelles found in most plant and animal cells that perform diverse metabolic functions including H2O2-based respiration, β-oxidation of fatty acids (FAs), and cholesterol metabolism.

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