What is CD123 a marker for?
Furthermore, CD123 is an important marker for the identification and targeting of LSCs for refractory or relapsed leukemia.
Do monocytes express CD123?
Definitely: yes the CD123 is present on monocytes and it is perfectly concfionnel and very useful.
Where is CD123 expressed?
Most notably, it was also shown that CD123 is expressed on both leukemic stem cells (LSC) as well as more differentiated leukemic blasts in both AML and BCP‐ALL, which makes CD123 an attractive therapeutic target 2. At present, various CD123 therapeutic monoclonal antibodies have entered clinical trials 3.
Do dendritic cells express CD33?
Dendritic cells subsets and Mo expressed low levels of CC and CXC receptors, but distinctive chemokine receptor expression profiles were not observed. All CD33(+) subsets migrated in a concentration dependent manner toward CCL19, but responded less robustly to CCL21. CCL20 was not chemoattractant for any population.
What is CD103 a marker for?
CD103 is the receptor for E-cadherin, which is expressed on epithelial cells, including renal tubular epithelial cells. Independent from its role in migration of immune cells, CD103 is also a marker of T cell activation (35).
What is Bpdcn?
A rare, fast-growing cancer that affects the blood, bone marrow, and skin. It can also affect the lymph nodes, spleen, and central nervous system. Most patients with BPDCN have red-brown or deep purple skin lesions on one or more areas of the body.
Where are monocytes made?
bone marrow
A type of immune cell that is made in the bone marrow and travels through the blood to tissues in the body where it becomes a macrophage or a dendritic cell.
Are Hematogones CD34 positive?
Hematogones are caraterized by very low side scatter (SSC) and dimmer expression of CD45 when compared to lymphocytes. They have variable (‘smeared’) expression of CD20; are positive for CD10 and partially for CD34 (B).
Are dendritic cells CD11b+?
The CD11b+ classical dendritic cell subset In the muscle and lamina propria, CD11b+ cDCs arise from cDC-restricted precursors and monocytes, but markers to distinguish the two ontogenically distinct subsets differ between tissues.
What does CD68 positive mean?
Fibrolamellar carcinomas are positive for CD68. Increased numbers of CD68-positive tumor macrophages indicate an adverse overall outcome in Hodgkin lymphoma. Significant co-localization of CD36 receptor with cells of the macrophage lineage, such as CD68 positive cells.
What is Ly6C marker?
Ly6C is a marker of macrophage subsets and support a model of selective recruitment of Ly6C(high) bone marrow monocytes to the kidney that differentiate into three populations of kidney macrophages, including a profibrotic Ly6C(low) population.
How rare is BPDCN?
BPDCN is a rare and aggressive hematologic malignancy that affects fewer than 1,000 people each year.
