What is the 6th chromosome responsible for?
Chromosome 6 spans more than 170 million base pairs (the building material of DNA) and represents between 5.5 and 6% of the total DNA in cells. It contains the Major Histocompatibility Complex, which contains over 100 genes related to the immune response, and plays a vital role in organ transplantation.
What is the 12th chromosome?
Chromosome 12 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 12 spans about 133 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells….
| Chromosome 12 | |
|---|---|
| GenBank | CM000674 (FASTA) |
What are the effects of chromosome 6 deletion?
Such features frequently include growth retardation before and after birth (prenatal and postnatal growth retardation) and associated short stature; poor muscle tone (hypotonia), psychomotor delays, and mild to profound mental retardation; craniofacial malformations; and/or ocular defects.
Why is chromosome 12 important?
Chromosome 12 contains several candidate genes that might be important in the development of atopy and asthma, including IFN-γ, stem cell factor (SCF), IGF-1, and the constitutive form of nitric oxide synthase (cNOS).
What does chromosome 12 affect?
Other changes in the number or structure of chromosome 12 can have a variety of effects on health and development. These effects include intellectual disability, slow growth, distinctive facial features, weak muscle tone (hypotonia), skeletal abnormalities, and heart defects.
How many base pairs does chromosome 6 have?
Chromosome 6 is a metacentric chromosome that constitutes about 6% of the human genome. The finished sequence comprises 166,880,988 base pairs, representing the largest chromosome sequenced so far.
How many cases are there of chromosome 6 deletion?
At present, there are 43 cases in the medical literature, excluding ring chromosome 6 anomalies. These include 27 reports on terminal deletions of 6p, six cases on unbalanced translocations, and the remaining 10 cases describe interstitial deletions with the entire 6p22, 6p22.
How is a translocation a chromosomal abnormality?
Narration. A translocation is a chromosomal abnormality whereby there’s a break in the chromosome, one particular chromosome, and that chromosome will then fuse to a different chromosome. And then you have what we call a fusion product.
Are there any rearrangements of the chromosome 6?
Rearrangements of chromosome 6 are prominent in chondromyxoid fibroma, commonly involving regions 6p23-25, 6q12-15, and 6q23-27 79,80. Two rearrangements, inversion inv (6) (p25q13) and translocation t (6;9) (q25;q22), have each been detected in two cases 81,82.
Are there any translocations between chromosomes 11 and 22?
One is a translocation between chromosome 11 and chromosome 22 and is known as the 11;22 translocation and another is a translocation between the short arms of chromosomes 4 and 8. Unique has published separate information guides for these translocations. How common is my particular balanced translocation?
What happens to chromosome 8 in a translocation product?
And what happens in these translocation products oftentimes, one gene on Chromosome 8 will be fused to a different gene of Chromosome 11, so you have a fusion gene.
