How do you dissolve doxorubicin?
Doxorubicin (hydrochloride) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, doxorubicin (hydrochloride) should first be dissolved in DMSO and then diluted with the aqueous buffer of choice.
Is doxorubicin soluble in water?
Doxorubicin hydrochloride is readily soluble in water, slightly soluble in normal saline, and sparingly soluble in alcohol.
How do you administer doxorubicin?
Doxorubicin is administered intravenously and intravesically and must not be administered orally, subcutaneously, intramuscularly or intrathecally. Doxorubicin can be administered intravenously as bolus within minutes, as short infusion for up to an hour or as continuous infusion for up to 96 hours.
Is doxorubicin hydrophilic or hydrophobic?
DOX·HCl is a water soluble chemotherapeautic agent, which becomes water insoluble when its HCl group is removed. Many DOX·HCl-loaded or DOX-loaded nanoparticles have been reported. However, it is not clear whether the salt form of doxorubicin influences its anti-tumor effect.
How do you make doxorubicin stock solution?
A stock solution may be made by dissolving the doxorubicin (hydrochloride) in the solvent of choice. Doxorubicin (hydrochloride) is soluble in DMSO and water. The solubility of doxorubicin (hydrochloride) in these solvents is approximately 10 mg/ml. Doxorubicin (hydrochloride) is sparingly soluble in aqueous buffers.
Can you freeze doxorubicin?
Doxorubicin hydrochloride, when reconstituted with sterile water for injection, may be refrigerated for six months or frozen for one month without loss of potency.
What is the structure of doxorubicin?
How long does doxorubicin stay in your system?
Doxorubicin causes your urine to turn reddish in color, which may stain clothes. This is not blood. It is to be expected and only lasts for 1 or 2 days after each dose is given.
How much does doxorubicin cost?
Doxorubicin is an anthracycline type of chemotherapy that is used to treat several different types of cancer. Learn more about this drug here. This is a generic drug. The average cost for 1 Vial, 25ml of 2mg/ml each of the generic (doxorubicin hcl) is $75.99.
What are the side effects of doxorubicin?
- Cough or hoarseness accompanied by fever or chills.
- darkening or redness of the skin (if you recently had radiation treatment)
- fast or irregular heartbeat.
- fever or chills.
- joint pain.
- lower back or side pain accompanied by fever or chills.
- pain at the injection site.
What kind of solubility does doxorubicin have in water?
Researchers have also demonstrated that doxorubicin effectively inhibits human DNA topoisomerase I (5). Solubility: Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming.
What is the molecular weight of doxorubicin DMSO?
Molecular Weight: 579.98 g/mol Solubility:Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming. Purity: >99%
How is doxorubicin used to inhibit topoisomerase I?
Researchers have also demonstrated that doxorubicin effectively inhibits human DNA topoisomerase I (5). Solubility: Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming. Directions for Use: Doxorubicin is supplied as a lyophilized powder.
How is desoxycorticosterone acetate soluble in water?
Desoxycorticosterone Acetate:White or creamy white, crystalline powder. Is odorless, and is stable in air. Practically insoluble in water; sparingly soluble in alcohol, in acetone, and in dioxane; slightly soluble in vegetable oils.