What does Ctgf stand for?
Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, angiogenesis, and wound healing, as well as multiple pathologies, such as tumor development and tissue fibrosis.
Is Ctgf a cytokine?
CTGF/CCN2. Connective tissue growth factor (CTGF or CCN2) is a prototypic member of the CCN family of cytokines.
What cell causes liver fibrosis?
Hepatic stellate cells (HSCs) play a key role in the fibrosis process, because in chronic liver damage, they transdifferentiate from a “quiescent” to an “activated” phenotype responsible for most the collagen deposition in liver tissue.
What is fg3019?
FG-3019 is a human anti-CTGF IgG1 monoclonal antibody currently under clinical investigation as a potential therapeutic for treatment of idiopathic pulmonary fibrosis, liver fibrosis and pancreatic cancer (5).
Can you stop liver fibrosis?
There is no specific treatment of liver fibrosis. Since it is a symptom of another liver problem, the most effective way to treat it is to address the underlying condition. Removing the cause of the liver damage will stop the fibrosis and allow the liver to heal. In the early stages, the damage is usually reversible.
What PRM 151?
PRM-151 is a recombinant human serum amyloid P/pentraxin 2 protein developed by Promedior, a biotechnology company developing therapies for fibrotic diseases using plasma-derived proteins and peptides. Promedior is currently focusing on rare systemic fibrotic diseases. …
How is connective tissue growth factor ( CTGF ) related to fibrosis?
When considered together, these data indicate that inhibition of CTGF can prevent and reverse the process of fibrosis. Connective tissue growth factor (CTGF, CCN2) is a member of a small family of proteins that are characterized by their highly conserved disulfide bonding pattern and having 3-4 domains with homology to other proteins [ 1, 2 ].
How does inhibition of CTGF affect tissue remodeling?
Thus, inhibition of CTGF in liver, the cardiovascular system or the lungs has the potential to reverse tissue remodeling and the process of fibrosis. Together, the results from these studies suggest that inhibition of CTGF may benefit any disease in which tissue remodeling is important.
How does CTGF interact with cytokines and growth factors?
CTGF interacts with a variety of molecules, including cytokines and growth factors, receptors and matrix proteins. These interactions alter signal transduction pathways, either positively or negatively, which results in changes in cellular responses.
Are there any monoclonal antibodies that treat CTGF?
A monoclonal antibody to CTGF that is currently in clinical development (FG-3019) has demonstrated the ability to reverse vascular stiffening and improve cardiac function in a rat model of diabetic complications. FG-3019 has also exhibited activity in a murine radiation-induced pulmonary fibrosis model.
