How do you give theophylline IV?
Intravenous Administration If the patient has received any theophylline within 24 hours, obtain serum theophylline concentration prior to administration of a theophylline loading dose. Manufacturers recommend administering the bolus dose over 30 minutes.
How can theophylline be administered?
Theophylline comes as an extended-release (long-acting) tablet, extended-release capsule, and a solution (liquid) to take by mouth. It usually is taken every 6, 8, 12, or 24 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Why is theophylline when administered intravenously is given as aminophylline?
Aminophylline is indicated for control of reversible airway constriction, to prevent bronchoconstriction, and as an adjunct with other respiratory disease treatment. The uses are similar to the indications for theophylline because it is a salt form of theophylline.
How often do you check theophylline levels?
Question: How often should a theophylline level be taken? Answer: In general, a level should be checked 1-2 times a year after a person is regulated. Of course, a person with variable levels should have his levels checked more often. If trouble breathing increases or side effects appear, then a level should be checked.
What are the side effects of theophylline?
Nausea/vomiting, stomach/abdominal pain, headache, trouble sleeping, diarrhea, irritability, restlessness, nervousness, shaking, or increased urination may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Can theophylline be given IV?
Intravenous (IV) Patients can be administered IV theophylline for acute bronchospasm. Those who are not currently taking theophylline should be given a loading dose of 5 to 7 mg/kg intravenously, followed by a maintenance dose of 0.4 to 0.6 mg/kg per hour intravenously to maintain serum concentrations at 10 to 15 mg/L.
Why is theophylline not used?
For maintenance therapy of asthma, theophylline may be obsolete because it is merely a relatively weak bronchodilator that adds little but side effects to dose- optimized inhaled ~2-agents and does not address the underlying inflammation, a fundamental charac- teristic of the disease.
How quickly does theophylline work?
This medication should take effect within 1 to 2 days, and you should see improvements in your pet’s clinical signs.
What is normal theophylline level?
Therapeutic serum levels of theophylline are between 10 to 20 mcg/ml. Most adults achieve these concentrations with daily slow-release oral theophylline preparations, 200-400 mg (approximately 10 mg/Kg) twice a day.
How is theophylline used in a hospital setting?
Theophylline injection is used together with other medicines to treat the acute symptoms of asthma, bronchitis, emphysema, and other lung diseases in a hospital setting. Theophylline belongs to a group of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs.
When to check theophylline levels after IV aminophyllines?
If converted from IV Aminophylline to oral Theophylline, check plasma theophylline level within 3 days; 4-6 hours after morning dose If oral theophylline is a new medicine (not converted from IV Aminophylline), check plasma theophylline level after 5 days of twice daily dosing; 4-6 hours after morning dose
How long does it take for theophylline to be absorbed?
Absorption: Theophylline is rapidly and completely absorbed after oral administration in solution or immediate-release solid oral dosage form. After a single dose immediate release Theophylline of 5 mg/kg in adults, a mean peak serum concentration of about 10 mcg/mL (range 5 to 15 mcg/mL) can be expected 1 to 2 hour after the dose.
How much theophylline do you need for bronchodilation?
Bronchodilation occurs over the serum Theophylline concentration range of 5-20 mcg/mL. Clinically important improvement in symptom control has been found in most studies to require peak serum Theophylline concentrations > 10 mcg/mL, but patients with mild disease may benefit from lower concentrations.
