Is onglyza safe for kidneys?
The DPP-4 inhibitor saxagliptin (Onglyza) appears to be safe in renal patients, researchers reported.
What class is Onglyza?
Onglyza carries the generic name saxagliptin. It belongs to a class of type 2 diabetes drugs called DPP-4 inhibitors. The first drug in this class, Merck’s Januvia, was approved in 2006. Like Onglyza, Januvia is taken once daily and is to be used in combination with diet and exercise.
What time of day should I take Onglyza?
You can generally take the tablet at a time of day to suit you, but it is best to take your doses at the same time of day each day. You can take saxagliptin before or after a meal.
What drug is comparable to Onglyza?
Tradjenta (linagliptin) and Onglyza (saxagliptin) are oral diabetes medicines used as adjuncts to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Side effects of Tradjenta and Onglyza that are similar include runny or stuffy nose, sore throat, cough, and headache.
How much does Onglyza lower A1C?
Pros and cons of Onglyza (saxagliptin) In clinical trials, was shown to lower A1C by 0.5%. There is a risk of heart failure while taking this medication.
How quickly does Onglyza work?
How long does it take for Onglyza (saxagliptin) to start working? Depending on the dose, the medication starts working within 4 to 5 days, but the full effects of this medication can take up to a few weeks in lowering your blood sugar and improving your A1c level.
How often should I take Onglyza for renal impairment?
Dosage in Patients with Renal Impairment. No dosage adjustment for ONGLYZA is recommended for patients with eGFR ≥45mL/min/1.73 m 2. The dosage of ONGLYZA is 2.5 mg once daily (regardless of meals) for patients with eGFR <45mL/min1.73 m 2 (which includes a subset of moderate or severe renal impairment, or with end-stage renal disease (ESRD)…
What is the use of Onglyza in type 2 diabetes?
Indication and Limitations of Use for ONGLYZA. ONGLYZA is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. ONGLYZA is not indicated for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis.
What are the side effects of Onglyza and saxagliptin?
Hypersensitivity reactions including anaphylaxis, angioedema, and exfoliative skin conditions Documented hypersensitivity (eg, anaphylaxis, angioedema, exfoliative skin conditions) Coadministration with thiazolidinediones (eg, rosiglitazone, pioglitazone) increases risk for peripheral edema
How much sulfonylurea can you take with saxagliptin?
Combination therapy: May need to reduce dosage of sulfonylurea or other insulin secretagogues when administered in combination Coadministration with strong CYP450 3A4/5 inhibitors: Not to exceed 2.5 mg PO qDay Peripheral edema (<4%; increased incidence when coadministered with thiazolidinediones)