Is silica harmful to human?
Crystalline silica has been classified as a human lung carcinogen, and can cause serious lung disease and lung cancer. One of the dangerous effects of silica exposure is a disease called silicosis, which can be contracted after just a few months of high exposure.
What is the most toxic and Fibrogenic form of silica?
Experimental evidence indicates that the toxicity of crystalline silica varies according to polymorphic form; cristobalite and quartz appear more reactive and more cytotoxic than coesite, shishovite and tridymite.
What causes silicosis?
Silicosis is a long-term lung disease caused by inhaling large amounts of crystalline silica dust, usually over many years. Silica is a substance naturally found in certain types of stone, rock, sand and clay. Working with these materials can create a very fine dust that can be easily inhaled.
What are the forms of silica?
The various forms of crystalline silica are: α-quartz, β-quartz, α-tridymite, β-tridymite, α-cristobalite, β-cristobalite, keatite, coesite, stishovite, and moganite (NIOSH, 2002).
Which of the following is NOT form of silica?
Tridymite is a form of quartz found in the form of crystals having thin hexagonal shapes in rocks and meteorites. It has a well defined arrangement. So, it is not the amorphous form of silica.
What does it mean to have primary adrenal insufficiency?
Adrenal insufficiency can be primary, secondary, or tertiary: Primary adrenal insufficiency. This is known as Addison disease. It occurs when the adrenal glands are damaged. They don’t make enough of the hormones cortisol and aldosterone. This condition is rare.
Can a lack of ACTH cause secondary adrenal insufficiency?
A lack of the hormone ACTH leads to secondary adrenal insufficiency. That can happen if you must take certain steroids for a long time due to a health problem. For example, people with asthma or rheumatoid arthritis may need to take prednisone. Other causes include: Pituitary gland is removed or you have radiation treatment of the pituitary gland
How is the ITT used to diagnose adrenal insufficiency?
A health care professional will draw your blood at the beginning of the test and again every half hour during the next 2 hours. If your cortisol levels are low, your pituitary isn’t making enough ACTH, so your adrenal glands don’t make enough cortisol. The ITT is the most reliable test to diagnose secondary adrenal insufficiency.
Is there a cure for adrenal gland insufficiency?
There is no cure available. Treatment requires the replacement or substitution of the hormones that the adrenal glands ceased to produce and should begin as soon as the diagnosis is confirmed. 5.1. Cortisol replacement