Which chemo drugs are neurotoxic?
The three most neurotoxic classes of anti-cancer drugs are: platinum-based drugs, taxanes, and thalidomide and its analogs; other, less neurotoxic but also commonly used drugs are: bortezomib, ixabepilone, and vinca alkaloids.
What is neurotoxic chemotherapy?
Neurotoxicity is the damage done to the nervous system when the brain is exposed to either a natural or artificial toxic substance. This substance alters the normal activity of the nervous system which results in damage. Both chemotherapy and radiation can be neurotoxic.
What are 3 methods of receiving chemotherapy?
Chemotherapy drugs can be given in a variety of different ways….Intravenous Chemotherapy Treatments
- An angiocatheter may be placed in a vein in the arm or hand and then removed after the chemo medication is given.
- PICC line.
- Non-tunneled catheters.
- Tunneled Catheters.
- Port-a-cath.
What is the most aggressive form of chemotherapy?
Doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers.
Are chemotherapy drugs neurotoxic?
Chemotherapy may cause both peripheral neurotoxicity, consisting mainly of a peripheral neuropathy, and central neurotoxicity, ranging from minor cognitive deficits to encephalopathy with dementia or even coma.
What kind of chemotherapy is associated with neurotoxicity?
Neurotoxicity Quick Facts. Background Neurotoxicity is a dose-limiting side effect of many different agents used in chemotherapy treatments; in particular, platinum drugs, including oxaliplatin, are associated with neurotoxicity. Oxaliplatin is an integral part of chemotherapy for colorectal cancer (CRC) in the adjuvant and metastatic setting.
What are some of the side effects of chemotherapy?
Chemotherapy may cause both peripheral neurotoxicity, consisting mainly of a peripheral neuropathy, and central neurotoxicity, ranging from minor cognitive deficits to encephalopathy with dementia or even coma. In this article we describe the neurological adverse effects of the most commonly used chemotherapeutic agents.
What kind of neuropathy can you get from chemotherapy?
These drugs are widely used for various malignancies such as ovarian and breast cancer, and haematological cancers. Chemotherapy-induced neuropathy is clearly related to cumulative dose or dose-intensities.
Can a bone marrow transplant cause neurotoxic effects?
Since bone marrow toxicity, as the major limiting factor in most chemotherapeutic regimens, can be overcome with growth factors or bone marrow transplantation, the use of higher doses of chemotherapy is possible, which increases the risk of neurotoxicity.
