Which drug is effective against Pseudomonas infection?
Pseudomonas infection can be treated with a combination of an antipseudomonal beta-lactam (eg, penicillin or cephalosporin) and an aminoglycoside. Carbapenems (eg, imipenem, meropenem) with antipseudomonal quinolones may be used in conjunction with an aminoglycoside.
What antibiotic has the worst activity against Pseudomonas?
The aminoglycoside group of antibiotics – amikacin – demonstrated maximum sensitivity against pseudomonas species. Therefore, use of amikacin should be restricted to severe nosocomial infections, in order to avoid rapid emergence of resistant strains.
What kind of bacteria are resistant to doripenem?
Doripenem does not have clinically useful activity against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and the majority of gram-negative bacilli that are resistant to meropenem or imipenem. In vitro, resistant P. aeruginosa mutants appear to be harder to select with doripenem than with other carbapenems.
What are the mics for imipenem and meropenem?
Although some isolates that are resistant to imipenem or meropenem (MIC, ⩾16 µg/mL) have doripenem MICs as low as 0.5 µg/mL, this seems to be the exception rather than the rule [ 14 ].
What is the mechanism of action of doripenem?
Mechanism of Action. Doripenem, like other β-lactam antibiotics, reacts with penicillin-binding proteins (PBPs) to form stable acyl-enzymes. This inactivates the PBPs, leading to a weakened cell wall, which eventually ruptures because of osmotic pressure forces [8].
When did doripenem get approved for hospital use?
Doripenem was approved by the US Food and Drug Administration (FDA) in 2007 for complicated intra-abdominal infection and complicated urinary tract infection. At the time this article was being written, the FDA was seeking additional information on doripenem before approval for use for hospital-acquired pneumonia.
