What is cyproterone acetate used for?
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an antiandrogen and progestin medication used in the treatment of androgen-dependent conditions such as acne, excessive hair growth, early puberty, and prostate cancer.
What happens when you take cyproterone acetate?
Cyproterone lowers levels of testosterone in the body and also blocks testosterone from reaching the cancer cells. It slows or stops the growth of prostate cancer.
Is cyproterone acetate A progesterone?
Cyproterone acetate is a synthetic progesterone derivative with antiandrogenic and progesterone-like activity used in the treatment of advanced prostate cancer. It is not approved by the FDA for use in the United States but is approved in other countries.
Is cyproterone acetate estrogen?
Each treatment cycle consists of one tablet, once per day for 21 days followed by a 7-day rest period. A total of 4 treatment cycles will be completed during the study treatment period. Ethinyl Estradiol (0.035mg) + Cyproterone acetate (2mg), coated tablets….Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation.
|Last Update Posted:||August 6, 2010|
|Last Verified:||April 2010|
When should I take cyproterone acetate?
How should I take/use this medication?
- Do not stop taking your medication without checking with your healthcare professional.
- You should take this medication after food.
- You may start taking this medication on the first or second day of your menses (if this is your first time taking hormonal contraceptives).
What is the best time to take cyproterone acetate?
When to take it Take your medicine after meals at about the same time each day. Taking it at the same time each day will have the best effect. It will also help you remember when to take it. Missed Androcur tablets may diminish the effectiveness of treatment and may lead to breakthrough bleeding in women.
Is cyproterone better than spironolactone?
On univariate analysis, the cyproterone group had significantly lower total testosterone concentrations (0.8 nmol/L (0.6–1.20)) compared with the spironolactone group (2.0 nmol/L (0.9–9.4), P = 0.037) and oestradiol alone group (10.5 nmol/L (4.9–17.2), P < 0.001), which remained significant (P = 0.005) after …
Is cyproterone acetate good for PCOS?
Objective: Ethinylestradiol (EE) combined with the antiandrogenic progestin cyproterone acetate (CPA) is a possible treatment in polycystic ovary syndrome (PCOS).
Why is cyproterone banned in the US?
Notably, although cyproterone has been used internationally for many years, it is not available in the US due to rare case reports of hepatotoxicity in men receiving high doses for prostate cancer (9).
What is the safest testosterone blocker?
Spironolactone. Evidence suggests that spironolactone is a very safe way to lower testosterone.
What is the IC50 of cyproterone acetate?
Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity.
What is the role of cyproterone acetate in the body?
Cyproterone acetate is a 20-oxo steroid, a 3-oxo-Delta (4) steroid, a chlorinated steroid, a steroid ester and an acetate ester. It has a role as an androgen antagonist and a progestin. It derives from a cyproterone. An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties.
What are the side effects of cyproterone therapy?
Cyproterone therapy can be associated with serum enzyme elevations during therapy and has been linked to many instances of clinically apparent acute liver injury, some of which were fatal. Cyproterone is a 20-oxo steroid, a 17alpha-hydroxy steroid, a chlorinated steroid, a 3-oxo-Delta (4) steroid and a tertiary alpha-hydroxy ketone.
How does cyproterone work on the androgen receptor?
Cyproterone, in its acetate form, binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation and inhibiting the growth of testosterone -sensitive tumor cells. This agent also exerts progesterogenic activity, resulting in a reduction in testicular androgen secretion and total androgen blockade. (NCI04)