What is LPL cancer?
Lymphoplasmacytic lymphoma (LPL) is a low-grade (slow-growing) non-Hodgkin lymphoma. It develops from B lymphocytes (a type of white blood cell) that become abnormal and grow out of control. White blood cells form part of your immune system, which helps fight infections.
How is lymphoplasmacytic lymphoma diagnosed?
Lymphoplasmacytic lymphoma is diagnosed by identifying small malignant lymphocytes in the bone marrow that are usually admixed with plasma cells, plasmacytoid lymphocytes, and/or mast cells. The small malignant lymphocytes can be monocytoid, centroblastic, or immunoblastic.
What is B cell lymphoma symptoms?
B-cell lymphoma also causes symptoms like these:
- Night sweats.
- Fever.
- Unexplained weight loss.
- Fatigue.
- Appetite loss.
- Trouble breathing.
- Pain or swelling in your belly.
- Severe itching.
Is lymphoplasmacytic lymphoma curable?
Waldenström macroglobulinemia (WM), also called “lymphoplasmacytic lymphoma,” is a rare, indolent (slow-growing) blood cancer that is treatable with available therapies but is not curable. Large amounts of an abnormal monoclonal protein called “immunoglobulin M” (IgM or “macroglobulin”) are produced.
What is the treatment for lymphoplasmacytic lymphoma?
People with lymphoplasmacytic lymphoma who have symptoms or hyperviscosity syndrome are usually given chemotherapy. Chemotherapy drugs that may be used with or without prednisone include: chlorambucil (Leukeran) fludarabine (Fludara)
How to detect CD10 expression in follicular lymphoma?
CD10 expression in follicular lymphoma and large cell lymphoma is different from that of reactive lymph node follicles Quantitative flow cytometry can detect significant differences in CD10 expression between normal follicular cells and follicular or diffuse large B-cell lymphoma.
Are there CD10 positive B cells in lymphoma?
CD10 expression was restricted to the bright CD20-positive cells, which accounted for an average of 16% of B cells. In CD10-positive follicular and diffuse large B-cell lymphoma cases, a significantly higher proportion of B cells (73%) coexpressed CD10.
What are the symptoms of lymphoplasmacytic lymphaoma ( LPL )?
Other symptoms of LPL may include: 1 weakness and fatigue (often caused by anemia). 2 fever, night sweats, and weight loss (generally associated with B-cell lymphomas). 3 blurred vision. 4 dizziness. 5 nose bleeds. 6 (more items)
What are the signs and symptoms of lymphoma?
Numbness, weakness, or other nervous system problems, pain in the hands or feet, sometimes called peripheral neuropathy Certain symptoms, called B symptoms, may signal a more aggressive cancer. Doctors may refer to either “A” or “B” when describing the lymphoma. A means that a person has not experienced B symptoms, listed below.
