What is the main component to synthesis aspirin?
salicylic acid
Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride. The molecular weight of aspirin is 180.16g/mol.
What is the limiting reagent in the synthesis of aspirin?
salicyclic acid
The acetic acid which is water soluble, can be separated from the aspirin by filtration. The salicyclic acid will be the limiting reagent.
What is the mechanism of action of aspirin?
He proved that aspirin and other non-steroid anti-inflammatory drugs (NSAIDs) inhibit the activity of the enzyme now called cyclooxygenase (COX) which leads to the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever.
Is aspirin soluble in water?
Aspirin is only slightly soluble in water so if you add it to the reaction mixture the product would rather clump together than be in the water phase. This causes the solid to begin to form or ‘precipitate’.
Which drugs are contraindicated with aspirin?
Who should not take ASPIRIN EC?
- systemic mastocytosis.
- low vitamin K levels.
- a type of joint disorder due to excess uric acid in the blood called gout.
- anemia.
- hemophilia.
- a decrease in the blood clotting protein prothrombin.
- blood clotting disorder – von Willebrand’s disease.
- decreased blood platelets.
How is the synthesis of aspirin carried out?
The synthesis of aspirin may be achieved in one simple step, O-acetylation of salicylic acid (Figure 1), which is incorporated into many undergraduate synthetic chemistry laboratory courses. The purity of the product as a pharmaceutical is crucial, and Objectives
How can aspirin be made from acetic acid?
Aspirin can be made by reacting salicylic acid with acetic acid in the presence of an acid catalyst. The phenol group on the salicylic acid forms an ester with the carboxyl group on the acetic acid. However, this reaction is slow and has a relatively low yield.
How to synthesize aspirin with ferric chloride?
1 Label three test tubes; place a few crystals of salicylic acid into test tube #1, a small sample of your aspirin… 2 Add 10 drops of 1% ferric chloride to each test tube. 3 Compare and record your observations.
How did Hippocrates invent the drug aspirin?
Acetylsalicylic acid is an acetic acid ester derivative of salicylic acid. The earliest known uses of the drug can be traced back to the Greek physician Hippocrates in the fifth century B.C. He used powder extracted from the bark of willows to treat pain and reduce fever.
