How would you prepare p Bromoacetanilide from acetanilide?
10 g of acetanilide is dissolved in 45 ml glacial acetic acid in a 250 ml conical flask and cooled to below 5 degrees. Then 4.2 ml of bromine is added drop wise in to 25 ml cold acetic acid with constant stirring and the bromine solution is transferred to a burette/separating funnel supported over the flask.
Which reagent is used to p Bromoaniline P Bromoacetanilide?
The invention discloses a preparation method of p-bromoaniline, and relates to the organic synthesis technical field; the preparation method comprises the steps: taking aniline as a raw material, firstly under the action of a zinc powder, carrying out an acetylation reaction with acetic acid to generate acetanilide.
Why glacial acetic acid is used in synthesis of P Bromoacetanilide from acetanilide?
Glacial acetic acid is not frozen ( cold) acetic acid. It is a common term used Glacial acetic acid is not frozen ( cold) acetic acid. This is why glacial acetic acid is used. Bromination of aromatic compounds (like aniline) using Bromine (Br2) takes place by electophilic aromatic substitution mechanism.
Why is P-Bromoacetanilide the major product?
because it is a bulkier group the substitution at the ortho position scarcely occurs, yielding the para mono-substituted compound as the major product (Scheme 5.1. 8.3). This compound, p-bromoacetanilide, already has the substitution pattern of the benzene ring that is desired for the final product.
What is the use of P Bromoacetanilide?
4-Bromoacetanilide was used as internal standard in determination of several phenylurea and triazine herbicides and their transformation products in oyster. It was used in the synthesis of new ligand for anchoring Gd(III) chelates onto TiO2 surface.
What is P bromoaniline?
CAS Name: 4-Bromobenzeneamine. Additional Names: 4-bromoaniline. Molecular Formula: C6H6BrN. Molecular Weight: 172.02.
What is P Bromoaniline?
Is P bromoaniline acidic or basic?
A higher pKa of the conjugate acid means that the substance is a stronger base. p-bromoaniline is the stronger base than m-bromoaniline.
Which structure is P Bromoaniline?
4-Bromoaniline is a compound where an aniline molecule is substituted with a bromine atom on the para position. Commercially available, this compound may be used as a building block, e.g. in the preparation of p-bromobiphenyl via the Gomberg-Bachmann reaction.
How to make P-bromoacetanilide from acetic acid?
Then 4.2 ml of bromine is added drop wise in to 25 ml cold acetic acid with constant stirring and the bromine solution is transferred to a burette/separating funnel supported over the flask. The bromine solution is added slowly with constant stirring to acetanilide solution and the flask is placed in cold water as the reaction is exothermic.
What is the chemical formula of P-bromoacetanilide?
Aim of the experiment was too brominate acetaldehyde to form p-bromoacetanilide. Acetanilide is a chemical compound with the chemical formula of C6H5NH (COCH3). It is a crystalline solid that is prepared by acetylation of analine and is widely used in the dye industry.
How to calculate the percentage yield of P-Bromo acetanilide?
The crude product is filtered with suction, the residue washed with cold water, recrystallized from rectified spirit, dried in an oven at 100 oC and the percentage yield is calculated. The p-bromo acetanilide is obtained as colourless crystals, m.p. 167°. Yield, 10 g.
When to add sodium bisulphite to para Bromo acetanilide?
Here para bromo acetanilide separates as a white solid. If the colour of the solution is persistently yellow, about 4-5 g of sodium bisulphite is added with constant stirring to bleach coloration.
