What are the defect of capsule?
CAPSULE SHELL PRODUCTION PROCESS
| DEFECTS | PROCESS RELATED CAUSES |
|---|---|
| Bubbles | Improper vacuum or duration of the gelatin bubbles extraction process. |
| Damaged print | Improper ink viscosity and applying pressure, uneven flow of the ink, clogged ink jets, incomplete drying of ink etc. |
What is the rate of capsule?
Patco Pharmaceuticals Empty Gelatin Capsule Size 0 (1000 Pcs)
| M.R.P.: | ₹499.00 |
|---|---|
| Price: | ₹409.00 Fulfilled |
| You Save: | ₹90.00 (18%) |
| Inclusive of all taxes |
What are the common problem encountered during manufacturing of capsules?
Moisture absorption is a relatively common problem encountered in the preparation of capsule products. The contents tend to become soft, agglomerate, and even mildew after moisture absorption; the capsule shells become soft and deformed after moisture absorption, thereby affecting the quality and efficacy of the drug.
How do you test capsules?
Finished capsules are evaluated by the following tests:
- a. Permeability and sealing.
- b. Potency and impurity content.
- c. Weight variation test.
- f. Uniformity of content.
- g. Disintegration time test for capsules.
- h. Dissolution test for capsules.
- i. Moisture content.
- j. Moisture permeation test.
What is telescopic defect in capsule?
Telescoping. This defect occurs when the cap and body misalign and the capsule body splits and a portion of it covers the cap. To eliminate this defect, make sure all the capsules are perfectly round. Also check the alignment of the cap and body bushings, or segments, using a gauge designed for that purpose.
What are the defects of tablets and classification?
Tablet specifications are tight, and the list of possible defects is long: Variable weight, sticking, picking, capping, lamination, variable hardness, among others.
What are the different types of capsules?
Selecting a capsule type
- Hard gelatin capsules.
- HPMC capsules.
- Fish gelatin capsules.
- Starch capsules.
- Pullulan capsules.
- Polyvinl acetate (PVA) capsules.
- Liquid-filled hard capsules (LFHC).
- Soft gelatin capsules (SGC).
How do you solve a capsule?
Capsule Formulas in terms of radius r and side length a:
- Volume of a capsule: V = πr2((4/3)r + a)
- Surface area of a capsule: S = 2πr(2r + a)
- Circumference of a capsule: C = 2πr.
What is the difference between hard and soft gelatin capsules?
Soft gelatin capsules are made from a relatively more flexible, plasticized gelatin film than hard gelatin capsules. Hard capsules, such as hard gelatin or HPMC capsules, are typically used for powder or solid fills, whereas soft gelatin capsules are used for semisolid or liquid fills.
What is capsule Dissectegration test?
Disintegration testing measures the ability of a tablet to break down into smaller particles or granules to allow the active drug to be absorbed into the body.
What are the defects in the capsule closing process?
Some of the most troublesome filled capsule defects occur in the capsule closing process, and are termed splits, telescoped capsules, folds and cap tucks. These defects occur during capsule closing, as the edges of the cap and body collide; in many cases causing product leakage.
How is defect detection used in capsule production?
Given the actual demand for capsule production, this study proposes a capsule defect detection and recognition method based on an improved convolutional neural network (CNN) algorithm. The algorithm is used for defect detection and classification in capsule production.
Are there any defects in pharmaceutical capsules manufacturing?
Real-time quality inspection of capsules manufacturing in pharmaceutical applications is an important issue from the point of view of industry productivity, competitiveness and quality aspect of the product. Pharmaceutical products are susceptible to several common flows like incorrect size or color, surface defect, missing, broken capsules.
What causes defects in sensum capsule filling process?
As you’ll notice, the defects are divided into two groups according to their source, which can be in capsule shell manufacturing or filling process. Furthermore, for each defect we have also determined the reasons for the occurrence. Improper storage conditions (exposure to light, heat, pH, microbial contamination etc.).
