Which of the Reoviruses proteins are responsible for virion binding to cells?
filamentous attachment protein
Reoviruses attach to host cells via the filamentous attachment protein, σ1. The σ1 protein of all reovirus serotypes engages junctional adhesion molecule-A (JAM-A), an integral component of intercellular tight junctions.
What do receptors do virus?
Viral receptors function not only as attachment moieties but also as entry factors, coordinators of viral trafficking, and activators of signaling events, and in many cases, viruses utilize multiple receptors to carry out different functions within the virus life cycle.
Why do cells have receptors for viruses?
As far as the virus is concerned, the role of its receptor in infection is to provide a point of attachment to a target cell and a signal that it is in an appropriate place to initiate the events leading to fusion with the cell membrane and entry of the virion components into a cell.
How does reovirus interact with β1 integrins?
Taken together, these results demonstrate that direct interaction of reovirus with β1 integrin mediates clathrin recruitment on host cells. To investigate whether reovirus can bind integrins, we used FD-curve-based AFM 11, 24 to quantify the binding strength of reovirus to β1 integrins both on model surfaces and living cells.
How does reovirus attach to cell surface receptors?
The initial attachment of reovirus virions to cell-surface receptors is mediated by σ1, which has binding sites for α-linked sialylated glycans (α-SA) 9 and junctional adhesion molecule-A (JAM-A) 10. The two commonly studied reovirus serotypes, T1 and T3, engage glycans and JAM-A, which act in concert through an adhesion-strengthening mechanism.
Where does replication take place in a reovirus?
Reovirus replication is cytoplasmic and a unique feature of these viruses is that transcription takes place from within capsids.
Which is a unique feature of the Reoviridae virus?
Reovirus replication is cytoplasmic and a unique feature of these viruses is that transcription takes place from within capsids. Virions are unenveloped, with two or three capsid layers (double or triple layer capsids). Middle and outer capsid layers are T =13 icosahedral lattices. The inner capsids or cores are T =1.
