Where is GFAP expressed in mouse brain?
GFAPδ is preferentially expressed by neurogenic astrocytes in the subventricular zone (SVZ), whereas GFAP(+1) is found in a subset of astrocytes throughout the brain.
What does GFAP stand for?
Glial fibrillary acidic protein (GFAP) is an intermediate filament that provides mechanical support to astrocytes.
Do neurons express GFAP?
Neurons express GFAP mRNA. A few NSE-immunopositive neurons in the hippocampus of an AD patient (NBB 83002) express GFAP mRNA (a and b, arrows).
What is GFAP in astrocytes?
Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system (CNS). Astrocytes have a range of control and homeostatic functions in health and disease.
What is GFAP antibody?
GFAP is a differentiation marker for astrocytes, and it is localized in normal central nervous system tissue, and certain tumor and metastases of the glial antigen. This antibody is suitable for immunofluorescent labeling of cultured mammalian cells.
What does positive for GFAP mean?
Intraleptomeningeal growing tumour cells presented usually a very strong positivity. In 8 recurring oligodendrogliomas, the number of GFAP positive tumour cells was the same in the primary tumour and in its recurrence. These results demonstrate that GFAP is not a specific astrocytic, but a glial-specific protein.
What causes GFAP?
GFAP: Glial fibrillary acidic protein. The degenerative brain condition called Alexander disease is caused by mutation in GFAP (glial fibrillary acidic protein). The GFAP gene provides instructions for making GFAP protein, a member of the intermediate filament family that provides support and strength to cells.
Are oligodendrocytes GFAP positive?
GFAP-positive progenitor cells produce neurons and oligodendrocytes throughout the CNS.
What happens if astrocytes are damaged?
Astrocytes can also react to brain injury and disease in various ways. Following nerve damage, for example, they form scar tissue that can aid in the regeneration of severed fibers. But they are also implicated in a wide variety of neurological and psychiatric diseases.
What is the function of GFAP?
GFAP is an intermediate filament protein (Eng et al., 2000) expressed primarily by astrocytes in the CNS. Its main function is to maintain astrocyte structural integrity and aid in cell movement and shape change (Eng et al., 2000).
