How do you dissolve doxorubicin hydrochloride?
Doxorubicin (hydrochloride) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, doxorubicin (hydrochloride) should first be dissolved in DMSO and then diluted with the aqueous buffer of choice.
How do you administer doxorubicin?
Doxorubicin is administered intravenously and intravesically and must not be administered orally, subcutaneously, intramuscularly or intrathecally. Doxorubicin can be administered intravenously as bolus within minutes, as short infusion for up to an hour or as continuous infusion for up to 96 hours.
What is the structure of doxorubicin?
C27H29NO11 (Doxorubicin)
Doxorubicin/Formula
How do you make doxorubicin stock solution?
A stock solution may be made by dissolving the doxorubicin (hydrochloride) in the solvent of choice. Doxorubicin (hydrochloride) is soluble in DMSO and water. The solubility of doxorubicin (hydrochloride) in these solvents is approximately 10 mg/ml. Doxorubicin (hydrochloride) is sparingly soluble in aqueous buffers.
How many doses of doxorubicin can you have?
Official Answer. In people at high risk of cardiotoxicity, the maximum lifetime cumulative dose of doxorubicin should not exceed 400 mg/m2.
What is the mode of action of doxorubicin?
Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation- …
What is the indication of doxorubicin?
Doxorubicin is also indicated for the treatment of cancers of the ovary, prostate, stomach, thyroid; small cell cancer of lung, liver; squamous cell cancer of head and neck; multiple myeloma, Hodgkin’s disease, lymphomas, acute lymphocytic leukemia (ALL), and acute myeloid leukemia (AML).
What kind of solubility does doxorubicin have in water?
Researchers have also demonstrated that doxorubicin effectively inhibits human DNA topoisomerase I (5). Solubility: Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming.
What is the molecular weight of doxorubicin DMSO?
Molecular Weight: 579.98 g/mol Solubility:Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming. Purity: >99%
How much light can doxorubicin hydrochloride be exposed to?
Several studies cite that stability is related to pH, exposure to light and the medium used for storage. Doxorubicin hydrochloride is subject to light degradation at <0.5 mg/mL, with considerable loss of bioactivity.
How is doxorubicin used to inhibit topoisomerase I?
Researchers have also demonstrated that doxorubicin effectively inhibits human DNA topoisomerase I (5). Solubility: Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming. Directions for Use: Doxorubicin is supplied as a lyophilized powder.
